Don’t Shy to use Generic Viagra
Contrary to the old belief that Viagra is a pill for the old people trying to keep up with their sexual urges, the drug has become useful even to younger men. Prevalently known as the blue pill, this recommended cure for impotence have seen a rising popularity down the age brackets marked by the increasing number of men especially under the age of 45 who have become victims of erectile dysfunction. This has seen the drug become one of the most sort cures for a condition that not has psychological implications on victims but also risk breaking their well founded relationships. The market has responded to this rising demand by production of generic Viagra.
Addressing to this issue of sexual health has been made easier for young men who can buy generic Viagra online. The pharmacy market has not been left behind as other markets take advantage of the internet platform to provide fast, secure and borderless markets as these products can be sold and shipped to people in need regardless of their location. Though it has to be used as per proper prescribed dosage, you buy Viagra online without prescription from online chemist accessible with the convenience on your laptop of smart phone. But the best move is to have advice on the use of the drug as it can have adverse side effects on a user.
If you are shying away from using this proclaimed cure for impotence because you young you can buy Viagra online and revitalize your sexual life. Sildenafil citrate should not only be used to keep your vegetables and fruits fresh for longer; you can use it to sustain a hard erection for longer. Simply kick your shy self away and let generic Viagra help you take back control of your sexual life to freely engage and enjoy lasting intimate sessions.
Cialis
Tadalafil is a drug used to treat erectile dysfunction under the brand name Cialis. It is also made in another formulation, Adcirca, in which form it is used to treat pulmonary arterial hypertension.
Also available: Generic Cialis

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Tadalafil is a drug used to treat erectile dysfunction under the brand name Cialis. It is also made in another formulation, Adcirca, in which form it is used to treat pulmonary arterial hypertension.

The drug was developed by a company known as ICOS but marketed by Lilly ICOS. This was a joint corporation formed by the merger of the ICOS Corporation and the Eli Lilly Company.

Pharmacology of Cialis

The active ingredient in Cialis is the chemical known as Tadalafil. This drug is part of a group of chemicals known as PDE5 inhibitors. The other drugs in this pharmacological group include sildenafil, which is popularly known as Viagra. The Cialis tablets are usually manufactured in the form of almond-shaped pills that are yellow in color and have a film coating.

The tablets come in varying concentrations of the active chemical, such as 5mg, 20mg or 10mg of Tadalafil per tablet. Cialis, along with other drugs such as Levitra and Viagra, are in a group of drugs used primarily to treat erectile dysfunction, a problem that affects a large proportion of men these days.

The pharmacological effects of Cialis and other related drugs stem from the fact that they inhibit phosphodiesterase 5 which is an enzyme which is responsible for the breakdown of a chemical known as cyclic GMP. The latter is usually found in smooth muscles in the lung arteries as well as blood vessels in the penis.

Its main action is to cause relaxation of the smooth muscles, which means that they can contain more blood. By inhibiting their destruction, Cialis ensures that one maintains an erection for much longer periods of time than usual.

The other pharmacological effect of Cialis is that due to its vasodilating properties, it can also increase the diameter of blood vessels in the lungs, which reduces the blood pressure within them. This is also useful when one is suffering from hypertension in the lungs.

When using Cialis, it is advised that one takes into consideration some of the evidence of the drug use from clinical studies. For instance, it has been shown that Cialis can cause a precipitous drop in blood pressure for individuals who are predisposed to certain heart conditions.

This means that if you have any heart disease, you should be careful about how much of the drug you take, lest you end up getting dangerous low blood pressure. For people with normal cardiovascular systems, however, the drug is safe.

In addition to that, clinical studies have also shown that the drug causes sudden loss of vision, especially if the drug is used by individuals who have preexisting visual disturbances.

That said, however, the drug has proven to be highly efficacious, a fact that is clearly observed when you realize that the drug is the preferred therapy for most people with erectile dysfunction.

Pharmacokinetics of Cialis

Absorption: Maximum plasma concentration of the drug is usually observed an average of two hours after ingesting the drug. However, individual statistics may vary, and it has been noted that the drug can be fully absorbed from between 30 minutes and 6 hours depending on one’s physiology. The absorption of the drug is not affected by food.

Distribution: The volume of distribution of this drug is around 63 liters. At therapeutic concentrations, around 90% of the drug in plasma is bound to plasma proteins. The drug is widely distributed in body tissues.

Metabolism: Cialis is metabolized by cytochrome enzymes, principally CPY3A4, into a catechol metabolite. This then undergoes methylation and glucuronidation to form the respective conjugates. The glucuronidated metabolites make up more than 90% of the metabolites of the drug. These metabolites have been shown to be pharmacologically active.

Elimination: Cialis has a clearance rate of 2.5 liters per hour. The average half-life termination of the drug is around 17.5 hours in healthy individuals. The drug is mainly eliminated in the feces as the metabolites, but around 36% of the dose is eliminated in urine as well.

Indications, dosage and side effects

Cialis is indicated for use in the treatment of erectile dysfunction in males. The standard dose usually prescribed is 10mg, but a large number of men find that lower doses such as 5mg may have the same effect.

Side effects of Cialis include headache, flushing, muscle aches, back pain, indigestion and having a runny nose. These side effects usually fade after a few hours.

However, back pain and muscle pain usually take a bit longer to disappear, but on average they usually go away in less than two days. Cialis should not be taken by individuals who have uncontrolled hypertension, hypotension or have suffered from a heart attack recently.

In addition to that, the drug is strongly contraindicated in patients who are currently taking nitrates for the treatment of angina and in people with irregular heartbeats.

Signs of overdose of Cialis include feeling light headed, chest pain, nausea and having an irregular heartbeat. It is advisable to seek emergency medical care when one overdoses on the drug.

Drug interactions

There are some drugs which can increase the metabolism of the drug by inducing the formation of CYP3A4 enzymes. These include protease inhibitors such as nelfinavir and ritonavir. Macrolide antibiotics such as clarithromycin and telithromycin also have the same effect, as do azole antifungals such as ketoconazole.

Other moderate inducers of the enzyme include some calcium channel blockers such as verapamil as well as erythromycin. These drugs blunt the efficacy of the drug in the body.

On the opposite end of the scale are drugs which increase the toxicity of Cialis by reducing the amount of degrading enzyme present. These include some hypoglycemic such as pioglitazone as well as barbiturates, bactericidals such as rifampicin and anticonvulsants.

Cialis affects the functioning of drugs such as antihypertensive drugs. Most of these are meant to induce vasodilation, which means that addition of Cialis to the regimen potentiates their effect. In addition to that, the drug also competes with other drugs for the CYP3A4 enzyme, which means that if an individual takes drugs that also depend on this enzyme for degradation, it may lead to toxicity of the other drug as it won’t be effectively eliminated from the body.

Cialis is meant to be stored in a cool, dry place away from the reach of children. If you are in need of the drug, you can easily buy a dose from your local pharmacist or in online stores.

Many of them require that you have a prescription before you can buy the drug. Generic Cialis is often cheaper than other kinds of Cialis, and can be found in online stores.
Discuss your past/current medical history in detail with your doctor before beginning treatment with any new medication. If you are using any herbal supplements or over the counter medication, including vitamin pills, then mention it to your doctor.

Please mention to your doctor if you have suffered from or are suffering from medical conditions like chest pain or heart problems.

Doctors advise against using the drug if you are allergic to any ingredient in it or if you are also using a nitrate drug for chest pain or heart problems. These include nitroglycerin (Nitrostat, Nitrolingual, Nitro-Dur, Nitro-Bid, Minitran, Deponit, Transderm-Nitro), isosorbide dinitrate (Dilatrate-SR, Isordil, Sorbitrate), isosorbide mononitrate (Imdur, ISMO, Monoket), or recreational drugs such as amyl nitrate or nitrite ("poppers").

Cialis when taken with a nitrate medicine can cause a serious decrease in blood pressure, leading to fainting, stroke or heart attack.

Tell your doctor if you have any of the following conditions before taking tadalafil:

• a recent history a heart attack (within the past 90 days);
• a recent history of stroke or congestive heart failure (within the past 6 months);
• angina (chest pain);
• high or low blood pressure;
• liver disease;
• kidney disease (or if you are on dialysis);
• a blood cell disorder such as sickle cell anemia, multiple myeloma, or leukemia;
• a bleeding disorder such as hemophilia;
• a stomach ulcer;
• retinitis pigmentosa (an inherited condition of the eye);
• a physical deformity of the penis (such as Peyronie's disease); or
• If you have been told you should not have sexual intercourse for health reasons.
Most medications have some kind of side effects associated with them. The commonest of these side effects are temporary though. These mild side effects fade away without any special attention or medical treatment.

These include headache, indigestion, back pain, muscle aches, flushing, and stuffy or runny nose. Back pain and muscle aches usually start within 12 to 24 hours after taking Cialis.

But if they persist or start to bother or affect your lifestyle, then you may seek medical attention.

Sexual stimulation is a must for Cialis to take effect.